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Circulating tenascin-C levels in patients with idiopathic dilated cardiomyopathy
Nobuko Aso1, Akira Tamura, Masaru Nasu
1Second Department of Internal Medicine, Oita University, Oita, Japan.
Abstract:
Circulating serum tenascin-C (an extracellular matrix glycoprotein) levels in patients with idiopathic dilated cardiomyopathy (IDC) were measured. Serum tenascin-C levels were increased in proportion to the severity of left ventricular dysfunction in patients with IDC. The associations of serum tenascin-C levels with serum troponin T and procollagen type III aminoterminal peptide levels suggest that increased levels of serum tenascin-C indicate ongoing replacement fibrosis after myocardial damage in IDC.
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