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Related Experiment Videos

Plasma and urinary catecholamines in primary fibromyalgia: a controlled study.

M B Yunus1, J W Dailey, J C Aldag

  • 1Department of Medicine, University of Illinois College of Medicine, Peoria 61656.

The Journal of Rheumatology
|January 1, 1992
PubMed
Summary

This study found no significant differences in plasma or urinary catecholamines between patients with primary fibromyalgia and healthy controls. Catecholamine levels did not correlate with fibromyalgia symptoms or psychological measures.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Clinical Medicine

Background:

  • Primary fibromyalgia (PF) is a chronic pain condition with complex pathophysiology.
  • Alterations in the sympathetic nervous system, including catecholamine levels, are hypothesized in PF.

Purpose of the Study:

  • To investigate potential elevations of plasma and urinary catecholamines in PF patients compared to healthy controls.
  • To examine correlations between catecholamine levels and clinical/psychological variables in PF.

Main Methods:

  • A blinded study measured plasma and urinary catecholamines in 30 PF patients and 30 healthy controls.
  • Clinical features and psychological measures were assessed in participants.

Main Results:

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  • No statistically significant differences in catecholamine levels were observed between the PF and control groups.
  • No significant correlations were found between catecholamine levels and clinical features or psychological measures in PF patients.

    • Conclusions:

    • The findings do not support the hypothesis of elevated catecholamines in primary fibromyalgia.
    • Catecholamine levels do not appear to be associated with the clinical or psychological characteristics of PF.