Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Functional consequences of 7TM receptor dimerization.

Jakob Lerche Hansen1, Søren P Sheikh

  • 1Laboratory of Molecular Cardiology, The Heart Centre and Copenhagen Heart Arrhythmia Research Centre (CHARC), Copenhagen University Hospital, Faculty of Health, University of Copenhagen, 20 Juliane Mariesvej, Denmark. jlhansen@molheart.dk

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
|November 30, 2004
PubMed
Summary

Seven-transmembrane (7TM) receptors form dimers, influencing their function. This review explores the biochemical evidence and functional impact of 7TM homodimerization in cell signaling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CD31<sup>+</sup> Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Correction to "NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin".

Journal of medicinal chemistry·2024
Same author

A Single Injection of ADRCs Does Not Prevent AAA Formation in Rats in a Randomized Blinded Design.

International journal of molecular sciences·2024
Same author

NN1213 - A Potent, Long-Acting, and Selective Analog of Human Amylin.

Journal of medicinal chemistry·2024
Same author

Epidemiological description and trajectories of patients with prostate cancer in Denmark: an observational study of 7448 patients.

BMC research notes·2023
Same author

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy.

Journal of visualized experiments : JoVE·2022

Area of Science:

  • Biochemistry
  • Cellular Biology
  • Pharmacology

Background:

  • Seven-transmembrane (7TM) receptors are crucial signaling platforms.
  • Emerging evidence suggests 7TM receptors form homo- and hetero-oligomers.
  • Oligomerization is implicated in receptor function, but its necessity for signaling is unclear.

Purpose of the Study:

  • To review the biochemical basis of 7TM homodimerization.
  • To discuss the characteristics and organization of 7TM homodimers.
  • To explore the functional consequences of 7TM homodimerization.

Main Methods:

  • Literature review of biochemical studies on 7TM homodimerization.
  • Analysis of dimer organization and functional impacts.
  • Inclusion of select heterodimerization examples for context.

Related Experiment Videos

Main Results:

  • Biochemical evidence supports 7TM homodimerization.
  • Dimerization influences receptor affinity, efficacy, trafficking, and signal transduction specificity.
  • The review focuses on homodimer characteristics and functional outcomes.

Conclusions:

  • 7TM homodimerization is biochemically supported and functionally significant.
  • Understanding homodimerization is key to deciphering 7TM receptor signaling mechanisms.
  • Further research is needed to confirm if dimerization is a prerequisite for 7TM signaling.