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Related Experiment Videos

Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing.

Ian J Deary1, Gillian Hamilton, Caroline Hayward

  • 1Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH89JZ, UK. i.deary@ed.ac.uk

Neuroscience Letters
|November 30, 2004
PubMed
Summary

Polymorphisms in the nicastrin (NCSTN) gene, specifically the B haplotype (Hap B), are linked to lifelong cognitive ability. This genetic factor influences verbal reasoning scores from age 11 through age 79.

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Area of Science:

  • Genetics
  • Neuroscience
  • Cognitive Aging

Background:

  • Cognitive aging is a complex process influenced by genetic and environmental factors.
  • Nicastrin (NCSTN) gene polymorphisms are potential candidates for influencing cognitive trajectories.
  • Understanding genetic contributions to cognitive stability is crucial for aging research.

Purpose of the Study:

  • To investigate the association between nicastrin (NCSTN) gene polymorphisms and cognitive abilities over a lifespan.
  • To determine if NCSTN gene variations impact cognitive level and age-related cognitive changes.
  • To analyze the influence of the NCSTN B haplotype (Hap B) on cognitive performance in a longitudinal cohort.

Main Methods:

  • A cohort of 462 participants from the Scottish Mental Survey 1932 was studied.

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  • Cognitive assessments, including verbal reasoning (Moray House Test), non-verbal reasoning, memory, and verbal fluency, were administered at ages 11 and 79.
  • Genotyping for NCSTN polymorphisms, specifically the B haplotype (Hap B), was performed.

    • Main Results:

    • Participants with at least one copy of the NCSTN B haplotype (Hap B) showed higher verbal reasoning scores at age 11 (p=0.036) and age 79 (p=0.027).
    • The effect of Hap B on age 79 cognition was not significant after accounting for age 11 scores, indicating an effect on stable cognitive ability.
    • The distribution of NCSTN genotypes was in Hardy-Weinberg equilibrium, suggesting the findings are not due to selection bias.

    Conclusions:

    • The NCSTN B haplotype (Hap B) is associated with stable, lifelong cognitive ability rather than age-related cognitive decline.
    • Genetic variations in NCSTN may play a role in individual differences in cognitive capacity.
    • Further research is warranted to elucidate the mechanisms underlying NCSTN's influence on cognition.