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Related Experiment Videos

Chlorpromazine inhibits cochlear function in guinea pigs.

John S Oghalai1

  • 1Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco, CA 94143-0342, USA. jso@bcm.tmcu.edu

Hearing Research
|November 30, 2004
PubMed
Summary

Chlorpromazine impairs cochlear amplifier function by altering outer hair cell (OHC) electromotility. This drug, like salicylate, increases hearing thresholds, demonstrating its effect on in vivo cochlear function.

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Area of Science:

  • Auditory Neuroscience
  • Otoacoustic Emissions
  • Hair Cell Physiology

Background:

  • Outer hair cell (OHC) electromotility is crucial for the cochlear amplifier's mechanical feedback.
  • In vitro studies show chlorpromazine shifts the OHC electromotility voltage-displacement transfer function.
  • Salicylate is known to reduce OHC electromotility magnitude.

Purpose of the Study:

  • To investigate the in vivo effects of chlorpromazine on cochlear function.
  • To compare the effects of chlorpromazine with salicylate on the auditory system.
  • To determine if chlorpromazine's in vitro effects translate to in vivo cochlear performance.

Main Methods:

  • Perilymphatic perfusion of chlorpromazine and salicylate in guinea pig cochleas.
  • Measurement of compound action potential (CAP) and distortion product otoacoustic emission (DPOAE) thresholds.

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  • Assessment of drug concentration-dependent effects and reversibility.

    • Main Results:

    • Both chlorpromazine and salicylate increased CAP thresholds across 1-20 kHz.
    • Both drugs elevated DPOAE thresholds at higher frequencies (10-20 kHz).
    • Observed effects were concentration-dependent, reversible, and consistent with in vitro data.

    Conclusions:

    • Chlorpromazine inhibits in vivo cochlear function, consistent with its effects on isolated OHCs.
    • The shift in OHC electromotility transfer function by chlorpromazine likely reduces cochlear amplifier gain.
    • These findings validate the role of OHC electromotility in maintaining normal hearing sensitivity.