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Updated: Aug 20, 2026
Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
[Effects of Xiaochaihu Tang, a traditional Chinese medicinal preparation, on ectopic endometrium in rats]
Hui Zheng1, Lian-dong Zuo, Hong-yi Li
1Department of Physiology, Medical College of Jinan University, Guangzhou 510632, China. lihzh@jnu.edu.cn
Objective:
To investigate the effects of Xiaochaihu Tang (XCHT), a traditional Chinese medicinal preparation, on ectopic endometrium in rats.
Methods:
In rat models of endometriosis, the effect of XCHT of ultrastructure of the ectopic endometrium was observed by transmission electron microscopy.
Results:
After treatment with XCHT at moderate (500 g/L) or high dose (750 g/L), ectopic endometrial growth was significantly inhibited (P<0.01); small-dose XCHT (250 g/L) was less effective (P<0.05). The volume of endometrium implant in the control group remained unchanged (P>0.05). The glandular cells in the endometrial implant after therapy with moderate- or high-dose XCHT showed characteristic features of apoptosis, presented by decreased cell size, karyopyknosis, cytoplasm and nuclear chromatin condensation, increased density and presence of apoptotic bodies. Some stromal cells displayed degenerative and necrotic changes.
Conclusion:
XCHT may inhibit the growth of ectopic endometrium by inducing cell death in the form of apoptosis and necrosis.