Related Experiment Video
Updated: Aug 11, 2026
08:46
Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
Published on: September 16, 2021
Can we eliminate severe ovarian hyperstimulation syndrome?
1Department of Obstetrics and Gynecology, Rabin Medical Center, Petah Tiqva 49 100 Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. orvieto@clalit.org.il
Human Reproduction (Oxford, England)
|November 30, 2004
Summary
This study introduces a triage strategy to prevent severe ovarian hyperstimulation syndrome (OHSS) in infertility treatments. It balances effective ovarian stimulation with reduced risks of OHSS and multiple pregnancies.
Area of Science:
- Reproductive endocrinology and infertility treatments.
Background:
- Couples seeking fertility treatment often accept risks for conception.
- Assisted reproduction technology (ART) aims to balance ovarian stimulation with successful outcomes while minimizing severe OHSS and multiple pregnancies.
- Complete prevention of severe OHSS is challenging, with hCG trigger withholding being the only definitive method.
Purpose of the Study:
- To present a triage strategy for eliminating severe OHSS occurrence in ART.
- To reduce the risk and severity of OHSS in susceptible individuals.
Main Methods:
- Utilizing GnRH antagonist in controlled ovarian stimulation protocols.
- Individualizing treatment based on patient risk factors and current cycle response.
- Implementing strategies such as freezing all embryos or single embryo transfer at the blastocyst stage.
Main Results:
- The proposed triage strategy aims to prevent severe OHSS.
- Individualized treatment and embryo cryopreservation/single transfer reduce OHSS risk and severity in susceptible patients.
Conclusions:
- A novel triage approach, incorporating GnRH antagonists and embryo cryopreservation or single embryo transfer, can effectively prevent severe OHSS.
- This strategy enhances patient safety in assisted reproduction while striving for successful treatment outcomes.
