Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Natural versus adaptive regulatory T cells.

Linda Cassis1, Sistiana Aiello, Marina Noris

  • 1Center for Research on Organ Transplantation, Chiara Cucchi de Alessandri e Gilberto Crespi, Mario Negri Institute for Pharmacological Research, Villa Camozzi, Ranica (Bergamo), Italy.

Contributions to Nephrology
|November 30, 2004
PubMed
Summary

Regulatory T cells (Treg) are crucial for immune tolerance. Specific Treg subsets, like CD4+CD25+ and CD8+CD28-, modulate responses to donor antigens, suggesting a role in human transplant tolerance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Moss-derived</i> recombinant Factor H, CPV-104, effectively antagonizes alternative pathway C3/C5 convertases stabilization by NeFs from patients with primary C3 glomerulopathy.

Frontiers in immunology·2026
Same author

Complement-Mediated Postpartum Atypical Hemolytic Uremic Syndrome With Collapsing Focal Segmental Glomerulosclerosis Associated With a Novel CFHR5 Copy Number Variant.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2026
Same author

Response to the Letter to the Editor Entitled "Defining "Dominance" in Atypical Hemolytic Uremic Syndrome: Distinguishing Amplification From Initiation".

Kidney international reports·2026
Same author

Molecular determinants of STEC-HUS: from complement activation to microvascular thrombosis.

Frontiers in immunology·2026
Same author

Complement Alternative Pathway Dominance in Atypical Hemolytic Uremic Syndrome Revealed by Endothelial Bioassays.

Kidney international reports·2026
Same author

Natural History and Clinical Associations with Long-Term Outcomes in Primary C3 Glomerulopathy and Immune Complex-Mediated Membranoproliferative GN.

Clinical journal of the American Society of Nephrology : CJASN·2025

Area of Science:

  • Immunology
  • Transplantation immunology

Background:

  • Regulatory T cells (Treg) are vital for maintaining self-tolerance and preventing autoimmune diseases.
  • Treg subsets, including CD4+ and CD8+ T cells, exhibit diverse phenotypes and functions.
  • Treg are implicated in preventing allograft rejection, as evidenced by animal models.

Purpose of the Study:

  • To explore the role of specific Treg subsets in modulating immune responses to donor antigens in human transplant patients.
  • To investigate the potential involvement of Treg in inducing or maintaining transplant tolerance in humans.

Main Methods:

  • Analysis of CD4+CD25+ and CD8+CD28- Treg populations in stable transplant recipients.
  • Assessment of Treg modulation of immune responses via direct and indirect pathways.

Related Experiment Videos

Main Results:

  • CD4+CD25+ Treg were found to modulate immune responses in the indirect pathway.
  • CD8+CD28- Treg were shown to modulate immune responses in the direct pathway.
  • These findings suggest a role for Treg in managing immune responses against donor antigens.

Conclusions:

  • Specific Treg subsets, CD4+CD25+ and CD8+CD28-, play distinct roles in modulating immune responses to donor antigens in human transplant recipients.
  • The identified Treg functions suggest a potential role in the induction or maintenance of transplant tolerance.
  • Further research into Treg mechanisms could inform strategies for improving transplant outcomes.