Related Experiment Video
Updated: Jul 15, 2026

Determining Soil-transmitted Helminth Infection Status and Physical Fitness of School-aged Children
Published on: August 22, 2012
The health and developmental status of very low-birth-weight children at school age
M C McCormick1, J Brooks-Gunn, K Workman-Daniels
1Department of Maternal and Child Health, Harvard School of Public Health, Boston, Mass 02115.
Insights
Children born at lower birth weights face more health issues at school age. Early intervention programs are crucial for improving outcomes for premature infants and reducing long-term health problems.
Area of Science:
- Pediatrics
- Neonatology
- Developmental Pediatrics
Background:
- Improved survival rates for premature infants necessitate understanding their long-term health outcomes.
- Assessing school-age outcomes provides critical insights into the effects of prematurity and low birth weight.
Purpose of the Study:
- To evaluate the school-age health status of children born at various birth weights, focusing on the impact of increasing survival rates of premature infants.
- To identify specific health morbidities and developmental outcomes associated with different birth weight categories.
Main Methods:
- Inception cohort study design.
- Inclusion of very low-birth-weight (<= 1500g) infants and a stratified random sample of heavier birth-weight children.
- Follow-up at 8-10 years using interviews and home/clinic visits for 65.1% of eligible participants.
Main Results:
- Decreasing birth weight correlated with increased morbidity across most measures, excluding affective health.
- Infants with birth weights <= 1500g had a higher likelihood of experiencing multiple health problems.
- Maternal education influenced IQ outcomes for children >1000g, with socioeconomic disadvantage negatively impacting all children regardless of birth weight.
Conclusions:
- Lower birth weight is associated with increased morbidity during early school years.
- Post-discharge and early intervention programs are vital for mitigating risks and improving long-term health for vulnerable children.
- Understanding these long-term outcomes emphasizes the need for continued support and monitoring of children born at low birth weights.
Objective:
To assess the effect of improved survival of increasingly premature infants by examining the outcomes at school age of a large group of children born at different birth weights.
Design:
Inception cohort.
Setting/Participants:
Participants were selected from two previously studied multisite cohorts: very low-birth-weight (less than or equal to 1500 g) children referred to participating intensive care units and heavier birth-weight children drawn from a stratified random sample of births in geographically defined regions. Follow-up at 8 to 10 years of age was by a combination of telephone interview and home/clinic visits for 65.1% (1868) of those eligible.
Main Outcome Measures:
The presence or absence of 17 specific conditions, limitations in activities of daily living due to health, mental health (affective health, behavior problems), and, for a subset, IQ scores.
Results:
Decreasing birth weight was associated with an increased morbidity for all measures except affective health; those with birth weights of 1500 g or less were more likely to experience multiple health problems. Maternal educational attainment did not influence the association of birth weight with morbidity except for IQ among children whose birth weight was above 1000 g, for which socioeconomic disadvantage worsened the status of all children irrespective of birth weight.
Conclusions:
Children born at lower birth weights experience increased morbidity at early school age. These results reinforce the importance of postdischarge, early intervention programs to reduce the risk of these later health problems.
Related Concept Videos
Nature and Nurture
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Pharmacokinetics in Pediatric Patients: Drug Distribution
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Development of Human Microbiota
Development of the Oral Microbiota

