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Related Concept Videos

Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...
Vascular Spasm01:16

Vascular Spasm

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Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Clot Retraction and Fibrinolysis01:16

Clot Retraction and Fibrinolysis

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Venous Thrombosis I: Introduction

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Related Experiment Video

Updated: Jul 15, 2026

Analysis of Physiologic E-Selectin-Mediated Leukocyte Rolling on Microvascular Endothelium
14:16

Analysis of Physiologic E-Selectin-Mediated Leukocyte Rolling on Microvascular Endothelium

Published on: February 11, 2009

P-selectin in arterial thrombosis.

M Merten1, P Thiagarajan

  • 1Herzzentrum, Medizinische Klinik III, Kardiologie und Angiologie, Universitätsklinik Hamburg-Eppendorf, Martinistr. 52, 20246 Hamburg, Germany. michael_merten@yahoo.com

Zeitschrift Fur Kardiologie
|November 30, 2004
PubMed
Summary

P-selectin, a key protein in arterial thrombosis, promotes platelet aggregation and leukocyte interactions. Inhibiting P-selectin interactions can reverse platelet aggregation, offering therapeutic potential.

Area of Science:

  • Biochemistry
  • Hematology
  • Immunology

Background:

  • P-selectin is a transmembrane protein found in platelets and endothelial cells.
  • It translocates to the cell surface upon activation.
  • Elevated P-selectin is linked to arterial thrombosis disorders like heart attack and stroke.

Purpose of the Study:

  • To elucidate the role of P-selectin in arterial thrombosis.
  • To understand P-selectin's mechanisms in platelet aggregation and leukocyte interactions.

Main Methods:

  • The study reviews P-selectin's functions based on existing research.
  • Mechanisms of P-selectin interaction with leukocytes (via PSGL-1) and platelets (via sulfatides) are discussed.

Main Results:

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In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells
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In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells

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Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
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Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis

Published on: January 9, 2026

Related Experiment Videos

Last Updated: Jul 15, 2026

Analysis of Physiologic E-Selectin-Mediated Leukocyte Rolling on Microvascular Endothelium
14:16

Analysis of Physiologic E-Selectin-Mediated Leukocyte Rolling on Microvascular Endothelium

Published on: February 11, 2009

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells
11:56

In vitro Method to Observe E-selectin-mediated Interactions Between Prostate Circulating Tumor Cells Derived From Patients and Human Endothelial Cells

Published on: May 15, 2014

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis
08:50

Thrombus Profiling Assay: A Microfluidics-Based Platform for Comprehensively Characterizing Biomechanical Thrombogenesis

Published on: January 9, 2026

  • P-selectin mediates platelet and leukocyte rolling on endothelial cells.
  • Platelet P-selectin binding to PSGL-1 on leukocytes promotes a prothrombotic state.
  • P-selectin stabilizes platelet aggregates by interacting with sulfatides, and its inhibition reverses aggregation.

Conclusions:

  • P-selectin is crucial for platelet aggregation and platelet-leukocyte interactions.
  • These interactions are significant contributors to the development of arterial thrombosis.
  • Targeting P-selectin interactions may offer therapeutic strategies for thrombotic diseases.