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Updated: Jul 26, 2026

Determining heat and mechanical pain threshold in inflamed skin of human subjects
Published on: January 14, 2009
[Topical application of morphine gel in inflammatory mucosal and cutaneous lesions]
1Abteilung für Anästhesiologie und allgemeine Intensivmedizin, LKH Klagenfurt.
Aim:
The aim of this study was to demonstrate a peripheral local opioid effect using case examples involving inflammatory mucosal and cutaneous lesions.
Methods:
A 0.1% morphine gel, mixed in the hospital pharmacy, was applied several times daily to inflammatory mucosal lesions (oral, anogenital and in one patient to a skin ulcer). The effects and side effects were documented.
Result:
All patients experienced a significant reduction in pain with the use of topical morphine gel and no side effects were seen.
Conclusion:
Topical peripheral application of morphine gel is a simple, effective method that can be carried out by patients several times a day with few side effects.
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