Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ceramide : A New Target in Anticancer Research?

Jean-Pierre Jaffrezou1, Guy Laurent

  • 1INSERM E9910, Institut Claudius Régaud, 31052 and Service d' Hematologie, Centre Hospitalier Universitaire Purpan, 31059, Toulouse, France. jaffrezou@icr.fnclcc.fr

Bulletin Du Cancer
|December 1, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quality of life of female partners of patients who underwent penile prosthesis implantation: A multicenter retrospective study.

The French journal of urology·2026
Same author

[The nurse at the heart of the assistance system for outpatients in the post-cancer period].

Revue de l'infirmiere·2022
Same author

Genomic stability at the coding regions of the multidrug transporter gene <i>ABCB1</i>: insights into the development of alternative drug resistance mechanisms in human leukemia cells.

Cancer drug resistance (Alhambra, Calif.)·2021
Same author

Posttraumatic Stress Disorder Symptoms in Lymphoma Patients: A Prospective Study.

Frontiers in psychiatry·2020
Same author

Psychotropic drug initiation in patients diagnosed with chronic myeloid leukemia: a population-based study in France.

Fundamental & clinical pharmacology·2020
Same author

Real-world costs of illness of Hodgkin and the main B-Cell Non-Hodgkin lymphomas in France.

Journal of medical economics·2019

Anticancer drug research is often empirical. A ceramide-mediated apoptotic pathway may offer new insights into chemotherapy and radiotherapy mechanisms, prompting debate on ceramide's role in cell death.

Area of Science:

  • Oncology
  • Cell Biology
  • Pharmacology

Background:

  • Anticancer drug discovery has historically relied on empirical methods with limited success in improving patient outcomes.
  • Traditional approaches focused on specific drug-target interactions for cell death and resistance, yielding suboptimal results.
  • The limitations of current strategies necessitate novel interpretations of drug action.

Purpose of the Study:

  • To review the emerging role of ceramide in apoptosis signaling pathways.
  • To debate whether ceramide acts as a consequence of cell damage or as an independent cytotoxic pathway component.
  • To explore new insights into the mechanisms of chemotherapy and radiotherapy.

Main Methods:

  • Literature review of recent findings on ceramide-mediated apoptosis.

Related Experiment Videos

  • Analysis of studies investigating antitumor agents and their interaction with ceramide pathways.
  • Discussion of existing concepts versus novel interpretations of drug action.

    • Main Results:

    • Identification of a ceramide-mediated apoptotic signaling pathway triggered by antitumor agents.
    • Evidence suggesting ceramide's involvement in cellular responses to chemotherapy and radiotherapy.
    • Emerging data challenges the solely damage-dependent role of ceramide.

    Conclusions:

    • Ceramide signaling represents a potentially crucial pathway in cancer therapy.
    • Further research is needed to elucidate whether ceramide is a cause or consequence of cellular damage in response to treatment.
    • Understanding ceramide's role may revolutionize anticancer drug development and therapeutic strategies.