[Correlation between some stress-realizing and stress-limiting systems in an acute period of ischemic stroke]

Concentrations of stimulating (glutamate, aspartate) and inhibitory (GAMK, glycin) amino acids were measured in cerebrospinal liquid of 67 patients with ischemic stroke. The condition of stress-realising and stress-limiting systems (SRS and SLS) was assessed by dynamics of stimulating and inhibitory amino acids. High and rapidly increasing concentration of glutamate within the first 24 h of the disease predicts a poor prognosis. Early rise of GAMK concentration is a favourable and reliable prognostic sign. Hyperactivation of glutamatergic system and deficiency of inhibitory GAMK-ergic system cause imbalance between mediators and metabolites of SRS and SLS. The severity and duration of this imbalance determine severity of clinical symptoms and outcome of the disease.