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A new ene-triyne antibiotic from the fungus Baeospora myosura
Craig A Parish1, Joann Huber, Jenny Baxter
1Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065-0900, USA. craig_parish@merck.com
Abstract:
The isolation and structure elucidation of 1 from the Basidomycete fungus Baeospora myosura is described. This new ene-triyne antibiotic was most potent against Gram-positive bacteria, while it was less active against Gram-negative bacteria and a yeast. MICs against several strains of Staphylococcus aureus were as low as 0.001 microg/mL. Analogues of 1 that did not contain the ene-triyne moiety were inactive against all microorganisms tested. The isolation of this new natural product was complicated by the highly reactive nature of the conjugated terminal polyacetylene.
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