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Apolipoprotein E polymorphism and lipoprotein compositions in patients with Behçet's disease
Umit Tursen1, Gulcin Eskandari, Tamer Irfan Kaya
1Department of Dermatology, University of Mersin School of Medicine, Mersin, Turkey. utursen@mersin.edu.tr
International Journal of Dermatology
|December 1, 2004
Summary
Behçet
Area of Science:
- Rheumatology
- Immunology
- Metabolic Research
Background:
- Behçet's disease (BD) is a multisystemic disorder with unknown causes, marked by recurrent oral-genital ulcers and uveitis.
- Previous research suggests potential alterations in lipoprotein metabolism within BD patients.
Purpose of the Study:
- To investigate apolipoprotein E (apo E) gene polymorphism and its association with lipoprotein cholesterol levels in Behçet's disease.
- To compare lipid profiles between BD patients and healthy controls.
Main Methods:
- Compared apolipoprotein E (apo E) genotypes and lipoprotein cholesterol concentrations in 30 BD patients versus 27 controls.
- Analyzed serum triglyceride, HDL, LDL, and VLDL cholesterol levels.
Main Results:
- Patients with BD exhibited significantly higher high-density lipoprotein (HDL) cholesterol levels compared to controls (P < 0.05).
- No significant differences were found in serum triglyceride, LDL, or VLDL cholesterol between groups.
- Apolipoprotein E (apo E) genotype and allele frequencies were similar between BD patients and controls, with no statistically significant variations.
Conclusions:
- Elevated HDL cholesterol levels in Behçet's disease patients are not attributable to apolipoprotein E (apo E) allele variations.
- Further research is needed to elucidate the underlying mechanisms of altered HDL cholesterol in BD.