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Oxidative stress and glucose levels in a population-based sample.
1Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, USA.
Diabetic Medicine : a Journal of the British Diabetic Association
|December 1, 2004
Summary
Elevated glucose levels impact oxidative status, increasing thiobarbituric reactive substances (TBARS) and decreasing glutathione (GSH). This suggests glucose influences the balance of oxidative and antioxidant processes in the population.
Area of Science:
- Biochemistry
- Metabolic Health
- Oxidative Stress Research
Background:
- Oxidative status is crucial for cellular function.
- Glucose metabolism is a key factor influencing metabolic health.
- Understanding the interplay between glucose and oxidative stress is vital for population health.
Purpose of the Study:
- To investigate the association between glucose levels and markers of oxidative status.
- To determine if glucose levels influence oxidative and antioxidant processes in a general population.
Main Methods:
- Population-based sample of 2300 adults (aged 35-79).
- Measured thiobarbituric reactive substances (TBARS), erythrocyte glutathione (GSH), and plasma glutathione peroxidase (GSH-Px).
- Categorized participants by glucose quartiles, fasting glucose abnormality, and diabetes metabolic control.
Main Results:
- Higher glucose quartiles correlated with increased TBARS and decreased GSH in both men and women.
- Impaired and abnormal fasting glucose in women was linked to higher TBARS, lower GSH, and higher GSH-Px.
- Poor metabolic control in diabetes was associated with significantly higher TBARS and GSH-Px.
Conclusions:
- Glucose levels significantly influence oxidative status in the population.
- The balance between oxidative and antioxidant processes is sensitive to glucose concentrations.
- Even moderate glucose elevations can alter oxidative status, highlighting potential health implications.