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Frequency and transmission mode of hepatitis C virus in northern Sindh

Majid Ahmed Shaikh1, Wazir Muhammad Shaikh, G Akber Solangi

  • 1Department of Medicine, Chandka Medical College, Larkana. majidahmed@yahoo.com

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|December 1, 2004
PubMed

Insights

Hepatitis C virus (HCV) is a major cause of chronic liver disease (CLD). Contaminated syringes were identified as the primary transmission route in this study.

Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Chronic liver disease (CLD) poses a significant global health burden.
  • Hepatitis C virus (HCV) is a primary etiological agent contributing to CLD.
  • Understanding HCV transmission is crucial for effective prevention strategies.

Purpose of the Study:

  • To determine the prevalence of Hepatitis C virus (HCV) infection in patients diagnosed with chronic liver disease (CLD).
  • To investigate the primary modes of HCV transmission within the studied patient cohort.
  • To identify key risk factors associated with HCV infection in individuals with CLD.

Main Methods:

  • A descriptive, non-interventional study design was employed.
  • Data was collected from 1074 patients with CLD admitted between January 1997 and December 2002.
  • Patient variables were systematically recorded and analyzed to assess HCV status and transmission factors.

Main Results:

  • The study included 1074 patients, with 564 diagnosed with chronic hepatitis and 510 with liver cirrhosis.
  • The male to female ratio was 2:1 across both chronic hepatitis and cirrhosis groups.
  • Anti-HCV antibodies were detected in 51% of chronic hepatitis patients and 57% of cirrhosis patients, with syringe use identified as a significant risk factor (62%).

Conclusions:

  • Hepatitis C virus (HCV) is a leading cause of chronic liver disease (CLD).
  • The predominant risk factor for HCV transmission identified in this study was the use of contaminated syringes.
  • Public health interventions should focus on safe injection practices to curb HCV spread.
Abstract

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