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Updated: Aug 20, 2026
Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Plasma lipid peroxides: relationships to cardiovascular risk factors and prevalent cardiovascular disease
A G Rumley1, M Woodward, A Rumley
1University Department of Medicine, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER. gdl1j@clinmed.gla.ac.uk
Background:
The epidemiology of plasma lipid peroxides, which may play a role in atherogenesis, has not been well defined.
Aim:
To study the relationships of plasma lipid peroxides to cardiovascular risk factors in a random population sample.
Design:
Random, age- and sex-stratified population sample.
Methods:
We studied 739 men and women aged 25-74 years. Lipid peroxides were assayed by the thiobarbituric acid (TBA) assay for malondialdehyde (MDA) in stored plasma samples.
Results:
Lipid peroxide levels increased with age. In men, lipid peroxides were significantly associated with smoking habit. Lipid peroxides correlated with non-fasting serum triglycerides (r = 0.33; p < 0.0001) in both sexes. Weaker associations were observed for cholesterol, high-density lipoprotein cholesterol (inversely), body mass index, fibrinogen and white cell count; as well as an inverse association with serum vitamin C in men.
Discussion:
These findings clarify the relationships of plasma lipid peroxides to cardiovascular risk factors; and are consistent with the hypothesis that lipid peroxidation may be one mechanism through which several risk factors may promote cardiovascular disease.
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