Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Single-chip mechatronic microsystem for surface imaging and force response studies.

Sadik Hafizovic1, Diego Barrettino, Tormod Volden

  • 1Physical Electronics Laboratory, Swiss Federal Institute of Technology, Hoenggerberg HPT-H4.2, Wolfgang-PauliStrasse 16, 8093 Zurich, Switzerland.

Proceedings of the National Academy of Sciences of the United States of America
|December 1, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A perfused, parallelized blood brain barrier-tumor platform for compound permeation and efficacy investigations.

Microsystems & nanoengineering·2026
Same author

Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na<sup>+</sup> channel dynamics in human neurons.

Molecular psychiatry·2026
Same author

Adaptation of <i>Enterococcus faecalis</i> to intestinal mucus revealed by a human colonic organoid model.

mSystems·2026
Same author

Preconfigured neuronal firing sequences in human brain organoids.

Nature neuroscience·2025
Same author

Lung basement membranes are compositionally and structurally altered following resolution of influenza infection.

Mucosal immunology·2025
Same journal

Costunolide ameliorates autoimmune uveitis by targeting USP15 to suppress TNF-α-induced retinal endothelial inflammation.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

A ligandable PNT domain establishes ERG as a directly targetable oncogenic driver in prostate cancer.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Identification of cellular intermediates unveils unique enzymes for flagellar glycan biosynthesis in <i>Clostridioides difficile</i>.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

The structure of correlated variability reflects task-relevant information in sensory neurons.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Shared neurogenetic substrates of nonplanning impulsivity and procrastination.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

HIV-1 capsid interactions with Nuclear Pore Complex components support nuclear entry via affinity gradient.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

This study presents a compact, single-chip atomic force microscopy (AFM) unit. This microelectromechanical system (MEMS) enables high-speed, cost-effective nanoscale imaging without external controllers.

Area of Science:

  • Nanotechnology
  • Microelectromechanical Systems (MEMS)
  • Atomic Force Microscopy (AFM)

Background:

  • Traditional atomic force microscopy (AFM) systems are often bulky and expensive.
  • Integration challenges limit the miniaturization and widespread adoption of AFM technology.

Purpose of the Study:

  • To develop a stand-alone, single-chip AFM unit.
  • To demonstrate the feasibility of a fully integrated microelectronic and micromechanical system for AFM operations.
  • To reduce the size and cost of AFM systems while increasing scanning speed.

Main Methods:

  • Fabrication of a 7 x 10 mm single-chip unit using complementary metal oxide semiconductor (CMOS) technology and micromachining.
  • Integration of an array of cantilevers with individual actuation, detection, and control units on-chip.

Related Experiment Videos

  • Implementation of on-chip circuitry including signal amplification, filtering, analog-to-digital converters, a digital signal processor, and a digital interface.

    • Main Results:

    • Achieved a vertical resolution of less than 1 nm.
    • Demonstrated a force resolution of less than 1 nN.
    • Successfully performed standard AFM operations using only the integrated chip.

    Conclusions:

    • The monolithic, single-chip AFM system represents a paradigm shift in mechatronic microsystems.
    • This technology enables precise mechanical manipulation and imaging in the nanoworld with reduced size and cost.
    • The developed system paves the way for more accessible and high-performance nanoscale characterization tools.