Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[ADHD and alcohol dependence: a common genetic predisposition?].

Norbert Wodarz1, Kirsten Lange, Rainer Laufkötter

  • 1Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität am Bezirksklinikum Regensburg. norbert.wodarz@medbo.de

Psychiatrische Praxis
|December 1, 2004
PubMed
Summary

Attention-deficit hyperactivity disorder (ADHD) often co-occurs with substance use disorders. This study found no shared genetic link via 5-HTT/5-HT2c alleles between adult ADHD and alcohol dependence in German alcoholics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HLA Profiles of Patients With Chronic Kidney Disease in Central South Africa.

International journal of nephrology·2026
Same author

Take-Home Naloxone in Opioid Dependency: An Intervention to Reduce Opioid-Related Deaths.

Deutsches Arzteblatt international·2025
Same author

Impact of opioid abuse on oral health: a retrospective cohort study.

Frontiers in oral health·2025
Same author

Opioid substitution treatment, relapse and addiction-related outcomes in prison setting and after release: A longitudinal study.

Nordisk alkohol- & narkotikatidskrift : NAT·2024
Same author

Prevalence of lupus nephritis and the use of serology in a central South African chronic kidney disease patient cohort.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2023
Same author

[First Aid Training for Drug Overdose in Opioid Addicts and Provision of Take-Home Naloxone on Release from Prison: Feasibility Study from the Bavarian Model Project].

Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·2022

Area of Science:

  • Neurogenetics
  • Psychiatry
  • Pharmacogenetics

Context:

  • Attention-deficit hyperactivity disorder (ADHD) frequently presents with comorbid substance use disorders in adulthood.
  • Both ADHD and alcohol dependence possess significant genetic components, suggesting potential shared genetic liabilities.
  • Understanding these genetic overlaps is crucial for developing targeted therapeutic strategies.

Purpose:

  • To investigate the potential shared genetic predisposition between adult ADHD and alcohol dependence.
  • To examine the allelic characteristics of the 5-HTT and 5-HT2c genes in individuals with alcohol dependence.
  • To determine if specific polymorphisms in these genes are associated with the comorbidity of ADHD and alcohol dependence.

Summary:

  • This study analyzed phenotype and 5-HTT/5-HT2c allelic variations in 314 individuals of German descent with alcohol dependence.

Related Experiment Videos

  • A significant portion (21%) of the alcohol-dependent subjects met DSM-IV criteria for adult ADHD.
  • No significant differences in 5-HTT or 5-HT2c allele distribution were observed between alcoholics and controls, or between alcoholics with or without ADHD.

    • Impact:

    • The findings suggest that the investigated 5-HTT-promoter and 5-HT2c-receptor polymorphisms do not contribute to the shared genetic predisposition between ADHD and alcohol dependence in this sample.
    • This research helps to refine our understanding of the genetic architecture underlying the comorbidity of these conditions.
    • Further research into other genetic factors and environmental influences is warranted to fully elucidate the complex relationship between ADHD and alcohol dependence.