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Serum leptin level in patients with functional dyspepsia
K B Lankarani1, M Moghadami, M Masoumpoor
1Gastroenterohepatology Research Centre, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. lankaran@sums.ac.ir
Summary
Serum leptin levels are elevated in functional dyspepsia, particularly the dysmotility subtype. This suggests leptin
Area of Science:
- Gastroenterology
- Endocrinology
- Pathophysiology
Background:
- Leptin regulates food consumption and has been identified in gastric mucosa.
- Functional dyspepsia (FD) is a common gastrointestinal disorder.
- Previous research indicates leptin's role in appetite regulation.
Purpose of the Study:
- To investigate the correlation between serum leptin levels and subtypes of functional dyspepsia.
- To explore the relationship between leptin and pathological findings in FD, including gastritis and Helicobacter pylori infection.
Main Methods:
- A prospective study involving 44 FD patients (dysmotility-like and ulcer-like) and 22 healthy controls.
- Serum leptin levels were measured.
- Antral biopsies were analyzed for gastritis intensity and H. pylori infection.
Main Results:
- Serum leptin levels were significantly higher in patients with dysmotility-like dyspepsia compared to controls.
- Leptin levels showed a significant correlation with the presence of gastritis and H. pylori infection.
- A notable association was found between elevated leptin and dysmotility-like functional dyspepsia.
Conclusions:
- Leptin may contribute to the pathogenesis of dysmotility-type non-ulcer dyspepsia.
- The role of leptin may extend beyond H. pylori infection in FD.
- Further research involving gastric leptin expression is warranted to understand its link with FD symptoms.