Effect of fluoropyrimidines on the growth of Ureaplasma urealyticum
Rahma Wehelie1, Staffan Eriksson, Liya Wang
1Department of Molecular Biosciences, Section of Veterinary Medical Biochemistry, The Swedish University of Agricultural Sciences, Uppsala, Sweden.
Abstract:
In the present study, we investigated the effect of fluoropyrimidines on the growth of Ureaplasma urealyticum. Addition of fluoropyrimidines strongly inhibited bacterial growth. Growth inhibition by these analogues could be reversed by addition of either thymidine or deoxyuridine, suggesting inhibition of thymidylate biosynthesis as the mechanism in operation.
Related Concept Videos
Inhibitors of Bacterial DNA Synthesis
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
Urine Studies II: Urine Culture and Sensitivity Test


