Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Eplerenone in hypertension.

Ellen Burgess1

  • 1University of Calgary, Department of Medicine, Faculty of Medicine, 2500 University Drive NW, Calgary, Alberta, T2N 1N4 Canada. Ellen.Burgess@CalgaryHealthRegion.ca

Expert Opinion on Pharmacotherapy
|December 2, 2004
PubMed
Summary

Eplerenone, a selective aldosterone antagonist, effectively lowers blood pressure with minimal sexual side effects compared to spironolactone. This well-tolerated antihypertensive agent offers a safe option for managing cardiovascular and renal diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Health Priorities and Intervention Preferences among Young Adult Cancer Survivors: A Mixed-Methods Study.

Journal of adolescent and young adult oncology·2026
Same author

A Remotely Delivered Light-Intensity Physical Activity Intervention for Older Cancer Survivors: Protocol for a Feasibility Randomized Controlled Trial.

JMIR research protocols·2024
Same author

Critical decisions: A mixed-methods study of decision-making among diverse gynecologic cancer patients considering therapeutic clinical trial enrollment.

Gynecologic oncology·2024
Same author

Differing Experiences of Nutrition Care During Treatment Among Oncology Nurses, Providers, and Patients.

Clinical journal of oncology nursing·2023
Same author

Erratum. Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study. Diabetes Care 2022;45:888-897.

Diabetes care·2023
Same author

A comparative post hoc analysis of finerenone and spironolactone in resistant hypertension in moderate-to-advanced chronic kidney disease.

Clinical kidney journal·2023

Area of Science:

  • Cardiology
  • Nephrology
  • Pharmacology

Background:

  • Aldosterone plays a significant role in cardiovascular and renal diseases.
  • Spironolactone, an older aldosterone antagonist, has limitations due to adverse sexual effects like gynaecomastia.
  • Eplerenone represents a newer, more selective aldosterone antagonist with a favorable safety profile regarding sexual side effects.

Purpose of the Study:

  • To review published trials on eplerenone's efficacy and tolerability as an antihypertensive agent.
  • To compare eplerenone's blood pressure-lowering effects with other antihypertensives like enalapril and losartan.
  • To assess the safety profile of eplerenone, particularly concerning sexual side effects and hyperkalemia.

Main Methods:

  • Systematic review of published clinical trials involving eplerenone.
  • Analysis of dose-response relationships for blood pressure reduction.
  • Comparison of eplerenone's efficacy and safety against placebo, enalapril, and losartan in diverse patient populations.

Main Results:

  • Eplerenone demonstrated a dose-dependent reduction in blood pressure (50-200 mg/day), comparable to enalapril.
  • The drug showed additive effects when combined with ACE inhibitors or ARBs and superior performance to losartan in African-American patients.
  • Hyperkalemia risk was low (<1% withdrawal), and adverse effects were generally similar to placebo, with minimal sexual side effects.

Conclusions:

  • Eplerenone is an effective and well-tolerated antihypertensive medication.
  • Its selectivity minimizes sexual side effects, offering an advantage over spironolactone.
  • Eplerenone can be used as monotherapy or in combination with other agents for blood pressure management, with careful monitoring for hyperkalemia.

Related Experiment Videos