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Updated: Aug 20, 2026

Preparation of Acute Human Hippocampal Slices for Electrophysiological Recordings
Published on: May 7, 2020
High-grade atrioventricular block triggered by spontaneous and stimulation-induced epileptic activity in the left
Dirk-Matthias Altenmüller1, Manfred Zehender, Andreas Schulze-Bonhage
1Epilepsy Center, University of Freiburg, Freiburg, Germany. altenm@nz.ukl.uni-freiburg.de
Abstract:
Cardiac bradyarrhythmias may play a pivotal role in the pathophysiology of sudden unexpected death in epilepsy (SUDEP). We describe a patient with left temporal lobe epilepsy in whom high-grade atrioventricular conduction blocks were triggered by both spontaneous and stimulation-induced epileptic activity in the left temporal lobe. Electrophysiological data obtained by surface and intracranial electrodes point to a cerebral cardioarrhythmogenesis in the left amygdala and anterior hippocampus.
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