Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Physiology of BDNF: focus on hypothalamic function.

Lucia Tapia-Arancibia1, Florence Rage, Laurent Givalois

  • 1Laboratoire de Plasticité Cérébrale, FRE 2693 CNRS, Université de Montpellier 2, Place Eugène Bataillon, 34095 Montpellier, Cedex 5, France. aranci@univ-montp2.fr

Frontiers in Neuroendocrinology
|December 2, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intranasal lipid nanocapsule administration of the new lipophenol quercetin-3-O-DHA-7-O-iPr reduces carbonyl stress and improves behavior in a mouse model of Alzheimer's disease.

Drug delivery and translational research·2026
Same author

Neurophysiological and neuroinflammatory adaptations to seizure activity in aging.

Neurobiology of disease·2025
Same author

Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models.

Nature neuroscience·2025
Same author

A photoswitchable positive allosteric modulator to control the activation of the metabotropic glutamate receptor 5 by light.

Biochemical pharmacology·2025
Same author

Advancing Alzheimer's disease pharmacotherapy: efficacy of glucocorticoid modulation with dazucorilant (CORT113176) in preclinical mouse models.

British journal of pharmacology·2025
Same author

Nose-to-brain delivery of DHA-loaded nanoemulsions: A promising approach against Alzheimer's disease.

International journal of pharmaceutics·2025
Same journal

Neuroendocrine mechanisms of stress-induced KNDy-GnRH pulse generator suppression: Linking HPA-axis activation to female reproductive dysfunction.

Frontiers in neuroendocrinology·2026
Same journal

Aging-related autonomic nervous system imbalance and adrenergic regulation of immunity: Implications for inflammaging, autoimmunity, and long COVID.

Frontiers in neuroendocrinology·2026
Same journal

Neuroactive steroids as targets of micro- and nano-plastics: Putative impact on brain function and disease.

Frontiers in neuroendocrinology·2026
Same journal

Systems neuroendocrinology in ME/CFS and long COVID: a chronobiological framework for hormone-based research.

Frontiers in neuroendocrinology·2026
Same journal

N-methyl-d-aspartate receptor subunits interacting with regulators mediate neuropathic pain: from mechanisms to therapy.

Frontiers in neuroendocrinology·2026
Same journal

Mechanisms of photoperiodic polyphenism in vertebrates.

Frontiers in neuroendocrinology·2026
See all related articles

Brain-derived neurotrophic factor (BDNF) is vital for neuron survival and adult brain functions like plasticity. Its expression changes with brain insults and may influence neurological disorders, highlighting its role in stress response.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Neurobiology

Background:

  • Brain-derived neurotrophic factor (BDNF) is a key neurotrophin involved in neuronal survival and differentiation.
  • BDNF interacts with Trk and p75(NGFR) receptors, playing roles in both development and adult brain functions, including plasticity.
  • BDNF gene regulation is complex, with expression influenced by neuronal activity, hormones, and various brain insults.

Purpose of the Study:

  • To review the role of neurotrophins, particularly BDNF, in the central nervous system (CNS).
  • To explore how BDNF expression is modified by brain insults and its potential contribution to pathologies like depression, epilepsy, and neurodegenerative diseases.
  • To highlight the function of neurotrophins as plasticity mediators crucial for adaptive processes, with a focus on the stress response.

Related Experiment Videos

Main Methods:

  • Literature review of neurotrophins, their receptors, and BDNF's role in the CNS.
  • Analysis of BDNF expression regulation by neuronal activity, hormones, and brain insults.
  • Examination of BDNF's involvement in neurological disorders and adaptive plasticity.

Main Results:

  • BDNF is crucial for neuronal development and adult functions, including plasticity.
  • Altered BDNF expression is linked to CNS insults and neurological conditions such as depression, epilepsy, Alzheimer's, and Parkinson's disease.
  • Neurotrophins, including BDNF, act as plasticity mediators, enhancing brain resilience and adaptive responses to stress.

Conclusions:

  • BDNF plays a significant role in maintaining CNS function, adapting to insults, and mediating plasticity.
  • Dysregulation of BDNF is implicated in various neurological and psychiatric disorders.
  • Understanding BDNF's function in the stress response is critical for developing therapeutic strategies for CNS pathologies.