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Assay Development for High-Throughput Drug Screening Against Mycobacteria
Published on: October 25, 2024
Mycobactericidal and tuberculocidal activity of Korsolex AF, an amine detergent/disinfectant product
A Hernández1, E Martró, L Matas
1Servicio de Microbiología, Hospital Universitario Germans Trias i Pujol, Departamento de Genética y Microbiología, Facultad de Medicina, Universidad Autónoma de Barcelona, 08916 Badalona, Barcelona, Spain.
Abstract:
The mycobactericidal and tuberculocidal activities of Korsolex AF against Mycobacterium tuberculosis, Mycobacterium avium-Mycobacterium intracellulare (MAI), Mycobacterium kansasii and Mycobacterium chelonae were determined using quantitative suspension and carrier tests. The effects of organic load and hard water were also considered. A clinical isolate of MAI was the most resistant of the four test organisms. A 2% solution had good mycobactericidal and tuberculocidal activities after 30 min of exposure. Although further evaluation using European standard tests is necessary, we conclude that Korsolex AF appears to be a promising product for the disinfection of hospital instruments contaminated with mycobacteria.
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