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High- versus low-dose oxytocin for augmentation or induction of labor
John H Patka1, Amy E Lodolce, Angela K Johnston
1Department of Pharmacy and Drug Information, Grady Health System, Atlanta, GA 30303-3031, USA. jpatka@gmh.edu
Objective:
To compare the use of high- and low-dose oxytocin for augmentation or induction of labor.
Data Sources:
Clinical trials were accessed through MEDLINE (1966-November 2003). Published literature relevant to the use of oxytocin for augmentation or induction of labor was evaluated.
Study Selection And Data Extraction:
Articles identified from the data sources were evaluated and included if they were clinical trials comparing high-versus low-dose oxytocin for augmentation or induction of labor.
Data Synthesis:
Oxytocin is a treatment of choice for augmentation and induction of labor; however, no consensus exists regarding optimal dosing. Relevant studies comparing high-dose (2-6 mU/min) and low-dose (1-2 mU/min) therapy for labor augmentation and induction were evaluated.
Conclusions:
High-dose oxytocin decreases the time from admission to vaginal delivery, but does not appear to decrease the incidence of cesarean sections when compared with low-dose therapy.
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