Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leigh's syndrome.

A A S R Mannan1, M C Sharma, P Shrivastava

  • 1Department of Pathology, All India Institute of Medical Sciences, New Delhi 110-029, India.

Indian Journal of Pediatrics
|December 2, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Illuminating native fluorescence signatures for cancer detection.

Proceedings of SPIE--the International Society for Optical Engineering·2026
Same author

A naturally brighter approach to colorectal cancer detection.

Proceedings of SPIE--the International Society for Optical Engineering·2025
Same author

Announcing the Asian Oceanian Society of Neuropathology guidelines for Adapting Diagnostic Approaches for Practical Taxonomy in Resource-Restrained Regions (AOSNP-ADAPTR).

Brain pathology (Zurich, Switzerland)·2023
Same author

Isolated manifesting carrier of Duchenne muscular dystrophy.

Neurology India·2018
Same author

Sporadic optico-acoustic degeneration with peripheral neuropathy.

Neurology India·2018
Same author

Cognition and P300 in epilepsy : an event related study.

Neurology India·2018
Same journal

A Prospective Model for Detecting Missed Appendicitis in Low-Risk Pediatric Patients: Correspondence.

Indian journal of pediatrics·2026
Same journal

Serum Periostin as a Biomarker in Pediatric Asthma: Findings from a Case-Control Study - Authors' Reply.

Indian journal of pediatrics·2026
Same journal

When the Eye Peels: An Unusual Harbinger of Kawasaki Disease - Correspondence.

Indian journal of pediatrics·2026
Same journal

Pediatric Sleep-Related Laryngospasm: Cause of Nocturnal Respiratory Distress.

Indian journal of pediatrics·2026
Same journal

Validation of DSD Interpreter, a Mobile Application for Point-of-Care Evaluation of Infants with Atypical Genitalia: Correspondence.

Indian journal of pediatrics·2026
Same journal

Prenatal Diagnosis and Genomics in India - Historical Review, Current Status and Road Ahead.

Indian journal of pediatrics·2026
See all related articles

Leigh

Area of Science:

  • Neurology
  • Pediatrics
  • Biochemistry

Background:

  • Leigh's subacute necrotizing encephalomyelopathy is a rare, progressive neurodegenerative disorder.
  • It primarily affects infants and young children, leading to severe neurological deficits.

Observation:

  • A 15-month-old female presented with acute respiratory distress, metabolic acidosis, and a history of developmental regression.
  • Brain imaging revealed characteristic lesions in the basal ganglia and thalamus.
  • Elevated serum lactate and lactate/pyruvate ratio indicated a metabolic defect.

Findings:

  • Neuropathological examination confirmed spongiosis, necrosis, and demyelination typical of Leigh's disease.
  • The findings correlated with the clinical presentation and neuroimaging results.

Related Experiment Videos

Implications:

  • This case highlights the importance of recognizing the clinical and imaging features of Leigh's disease in infants.
  • Early diagnosis and understanding of the underlying metabolic derangements are crucial, although treatment options remain limited.