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Cyclodextrin-based pharmaceutics: past, present and future.

Mark E Davis1, Marcus E Brewster

  • 1Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA. mdavis@cheme.caltech.edu

Nature Reviews. Drug Discovery
|December 2, 2004
PubMed
Summary
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Cyclodextrins, biocompatible glucose derivatives, form complexes to enhance drug delivery. Cyclodextrin polymers offer unique capabilities for delivering nucleic acids, expanding therapeutic potential.

Area of Science:

  • Biochemistry and Pharmaceutical Sciences
  • Polymer Chemistry and Drug Delivery

Background:

  • Cyclodextrins are cyclic oligosaccharides derived from glucose.
  • They form water-soluble inclusion complexes with various molecules.
  • Cyclodextrins exhibit biocompatibility, low toxicity, and minimal immunogenicity.

Purpose of the Study:

  • To review current cyclodextrin-based therapeutics.
  • To discuss future applications of cyclodextrins in medicine.
  • To present cyclodextrin-containing polymers for drug delivery, particularly nucleic acids.

Main Methods:

  • Literature review of cyclodextrin applications in pharmaceuticals.
  • Analysis of current cyclodextrin-based drugs and their mechanisms.
  • Examination of research on cyclodextrin-containing polymers for drug delivery.

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Main Results:

  • Cyclodextrins effectively improve drug bioavailability and solubility.
  • Cyclodextrin-containing polymers demonstrate significant potential in advanced drug delivery systems.
  • These polymers offer unique advantages for the targeted delivery of nucleic acids.

Conclusions:

  • Cyclodextrins are versatile pharmaceutical excipients with established therapeutic uses.
  • Cyclodextrin-containing polymers represent a promising frontier for novel drug and nucleic acid delivery strategies.
  • Further research into cyclodextrin polymers could unlock new treatment modalities.