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Published on: January 14, 2017
[Study on in vitro and in vivo antibacterial activity of pheromonicin-SA]
Objective:
To evaluate the bactericidal activity of pheromonicin-SA (Ph-SA) via routine in vitro/in vivo measurement.
Methods:
Minimal inhibitory concentration (MIC50 and MIC90) of Ph-SA were evaluated via in vitro double-dilution assay with 69 strains pathogenic bacteria and via intraperitoneal infected mice with intravenous Ph-SA treatment.
Results:
In vitro data showed that bactericidal activity of Ph-SA was approximately 12 times greater, on a molar basis, than that of vancomycin. In vivo data showed that bactericidal activity of Ph-SA was approximately 59 times greater than that of vancomycin.
Conclusion:
The results suggest that Ph-SA may be of potential value as antibiotic against methicillin-resistant Staphylococcus aureus (MRSA).

