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Updated: Aug 19, 2026
Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
Published on: July 1, 2013
[Study on chronic toxicity to rats of implantation of super-high molecular weight polylactate]
Lei Liu1, Sheng-wei Li, Wei-dong Tian
1West China School of Stomatology, Sichuan University, Chengdu 610041, China.
Objective:
To make sure whether super-high molecular weight polylactate is toxic to the body after it has been implanted into the body for a long period.
Methods:
We implanted super-high molecular weight polylactate into the rats and took the specimens of blood at 3, 6, 9, 12 months after the operation. The changes of proteins, electrolyte, enzyme and other indices were observed. At the same time, the tissue around the implants were taken out to carry out the histological observation.
Results:
At 3, 6, 9, 12 months after the operation, the levels of albumin, globulin, total bilirubin, direct bilirubin, triglyceride, glucose, K+, Na+, Cl-, Ca2+, alkaline phosphatase, glutamic-pyruvic transaminase in the blood plasma were all in the normal range; there were no significant differences between the experimental group and the control group. The level of lactate dehydrogenase increased slightly, but there was no statistically significant difference between the experimental group and the control group. There were no non-reversible immune rejection around the implants in the histological observation.
Conclusion:
Super-high molecular weight polylactate is not toxic to the body after it has been implanted into the animals for a long period.
