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[Comparison of hepatic protein synthesis function between Banna Minipig Inbred Line and human]
Lin Zhang1, You-ping Li, Jing-qiu Cheng
1Lab of Transplant Engineering and Immunology, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
This is a research aimed at comparing the hepatic protein synthesis function of Banna Minipig Inbred Line (BMI) with that of human so as to evaluate the possibility of porcine liver replacement of human counterpart.
Methods:
The venous blood samples from BMI and volunteer participants were collected. The albumin and total protein in the separated sera were tested using Beckman delta CX7 autoanalyzer, and serum protein electrophoresis was performed.
Results:
No significant differences in albumin and in the percentage and concentration of globulins synthesized in liver (alpha1-, alpha2- and beta-globulin) between BMI and human were observed. The percentage and concentration of gamma-globulin synthesized in the lymphocytes of BMI were significantly higher than those of human.
Conclusion:
The above findings suggested the similarity between BMI liver and human liver in respect to albumin and alpha, beta-globulin synthesis.
