Related Experiment Video

Updated: Aug 4, 2026

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
08:43

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Published on: April 3, 2018

TGF-beta signal transduction in oro-facial health and non-malignant disease (part I)

S S Prime1, M Pring, M Davies

  • 1Department of Oral and Dental Science, Division of Oral Medicine, Pathology and Microbiology, Bristol Dental Hospital and School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK. Stephen.prime@bristol.ac.uk <Stephen.prime@bristol.ac.uk>

Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists
|December 3, 2004
PubMed

Insights

Transforming growth factor-beta (TGF-beta) regulates cell processes vital for health and disease. This review details TGF-beta activation, signaling, and its role in craniofacial development and non-malignant conditions.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Developmental Biology

Background:

  • The transforming growth factor-beta (TGF-beta) family comprises multi-functional cytokines.
  • TGF-beta regulates critical cell processes like proliferation, differentiation, and apoptosis.
  • It plays a significant role in both normal physiology and disease states.

Purpose of the Study:

  • To review the mechanisms of TGF-beta activation.
  • To detail TGF-beta signal transduction pathways.
  • To summarize TGF-beta's role in craniofacial development and non-malignant diseases.

Main Methods:

  • Literature review of existing research on TGF-beta.
  • Analysis of studies on TGF-beta activation and signaling pathways.
  • Synthesis of evidence implicating TGF-beta in physiological and pathological processes.

Main Results:

  • TGF-beta activation and signaling pathways are complex.
  • TGF-beta is implicated in craniofacial development (palatogenesis, tooth formation).
  • TGF-beta is involved in wound healing, scarring, and diseases like scleroderma and periodontal disease.

Conclusions:

  • TGF-beta is a key regulator of cell behavior in health and disease.
  • Understanding TGF-beta mechanisms is crucial for studying craniofacial development and related pathologies.
  • Further research into TGF-beta's role can inform therapeutic strategies for non-malignant conditions.

More Related Videos

Studying TGF-&#946; Signaling and TGF-&#946;-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells06:54

Studying TGF-β Signaling and TGF-β-induced Epithelial-to-mesenchymal Transition in Breast Cancer and Normal Cells

Published on: October 27, 2020

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis07:26

Isolation of Whole Cell Protein Lysates from Mouse Facial Processes and Cultured Palatal Mesenchyme Cells for Phosphoprotein Analysis

Published on: April 1, 2022

Related Concept Videos

TGF - &#946; Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors are of three kinds RI, RII, and RIII. The RI...
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...