Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T-cell division and aging.

H Gershon, S Merhav, C Abraham

    Mechanisms of Ageing and Development
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Aging T-cells show reduced reactivity due to a smaller responding cell population, not altered cell cycle dynamics. This impacts mixed lymphocyte reactivity and concanavalin A responses in senescent mice.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    First evidence of legacy and emerging per- and polyfluoroalkyl substances (PFAS) in the follicular fluid of a cohort of North Carolina in vitro fertilization (IVF) patients.

    Reproductive toxicology (Elmsford, N.Y.)·2025
    Same author

    "Depth of the dorsal nerve of the clitoris: Implications for cosmetic and urogynecologic surgery."

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS·2022
    Same author

    "I realised it weren't about spending the money. It's about doing something together:" the role of money in a community empowerment initiative and the implications for health and wellbeing.

    Social science & medicine (1982)·2020
    Same author

    Trial protocol: a clustered, randomised, longitudinal, type 2 translational trial of alcohol consumption and alcohol-related harm among adolescents in Australia.

    BMC public health·2018
    Same author

    Erratum to "Brief interventions to prevent sexually transmitted infections suitable for in-service use: A systematic review" [Prev. Med. 91 (2016) 364-382].

    Preventive medicine·2016
    Same author

    The impact of interventions to promote healthier ready-to-eat meals (to eat in, to take away or to be delivered) sold by specific food outlets open to the general public: a systematic review.

    Obesity reviews : an official journal of the International Association for the Study of Obesity·2016
    Same journal

    Human sex-specific hormone effects on cerebrovascular health in males and females.

    Mechanisms of ageing and development·2026
    Same journal

    HTZ-1/H2A.Z expression sustains transcriptional programs that regulate Caenorhabditis elegans lifespan.

    Mechanisms of ageing and development·2026
    Same journal

    PCSK9 promotes aging-related cardiac calcification by inducing osteogenic differentiation of cardiac fibroblasts.

    Mechanisms of ageing and development·2026
    Same journal

    Distinct post-infectious TLR2 immune remodeling in COVID-19-recovered centenarians.

    Mechanisms of ageing and development·2026
    Same journal

    Senescence-associated tertiary lymphoid structures in Sjögren's disease model nishiura mice.

    Mechanisms of ageing and development·2026
    Same journal

    Aging-driven reprogramming of CD34⁺ hematopoietic stem cells in leukemogenesis: Mechanisms and therapeutic implications.

    Mechanisms of ageing and development·2026
    See all related articles

    Area of Science:

    • Immunology
    • Gerontology
    • Cell Biology

    Background:

    • Mixed lymphocyte reactivity and responses to mitogens like concanavalin A are crucial measures of T-cell function.
    • Age-dependent declines in immune responses are well-documented but the underlying cellular mechanisms require further elucidation.

    Purpose of the Study:

    • To investigate the cellular basis for age-related decreases in T-cell proliferation observed in mixed lymphocyte reactions and concanavalin A stimulation.
    • To determine if changes in cell cycle kinetics or proliferative capacity contribute to diminished T-cell function in aging mice.

    Main Methods:

    • Assessing mixed lymphocyte reactivity and concanavalin A responsiveness in lymph node and spleen cells from C57Bl/6J female mice of varying ages.
    • Conducting cell cycle analyses to evaluate the proliferative capacity and division potential of responding T-cells.

    Related Experiment Videos

    Main Results:

    • The age-dependent decline in mixed lymphocyte reactivity was consistent across different stimulator cell incompatibilities (H-2 and Mls).
    • Neither the peak response time nor the sensitivity to stimulator cell concentration changed with age.
    • Cell cycle studies revealed that the kinetics of cell division and the capacity for re-division remained unchanged with donor age.

    Conclusions:

    • The reduced T-cell proliferation in senescent mice is attributed to a smaller pool of reactive T-cells, rather than alterations in cell cycle duration or proliferative potential.
    • These findings highlight a quantitative deficit in T-cell responsiveness with aging, rather than a qualitative defect in the cell division machinery.