Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Host cell-pathogen interface: molecular mechanisms and genetics.

Ralf R Schumann1

  • 1Institute for Microbiology and Hygiene, Charité University Medical Center, Humboldt-University and Free University Berlin, Dorotheenstr. 96, Berlin, Germany. ralf.schumann@charite.de

Vaccine
|December 4, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Dissecting the genetic heterogeneity of gastric cancer".

EBioMedicine·2023
Same author

Dissecting the genetic heterogeneity of gastric cancer.

EBioMedicine·2023
Same author

A Genetic Variation of Lipopolysaccharide Binding Protein Affects the Inflammatory Response and Is Associated with Improved Outcome during Sepsis.

ImmunoHorizons·2021
Same author

Interaction of TLR4 and TLR8 in the Innate Immune Response against Mycobacterium Tuberculosis.

International journal of molecular sciences·2021
Same author

RNA Sensing of <i>Mycobacterium tuberculosis</i> and Its Impact on TB Vaccination Strategies.

Vaccines·2020
Same author

A SNP upstream of the cyclic GMP-AMP synthase (cGAS) gene protects from relapse and extra-pulmonary TB and relates to BCG vaccination status in an Indian cohort.

Genes and immunity·2019
Same journal

V-safe: Summary of findings reported after COVID-19 vaccination to a US CDC active safety surveillance system through June 2023.

Vaccine·2026
Same journal

In silico selection and in vivo evaluation of scoloptoxin SSD14, Rm-inositol monophosphatase, and Rm-neprilysin as potential anti-tick vaccines.

Vaccine·2026
Same journal

Phase 1 trial of intranasal NDV-HXP-S in previously vaccinated adults.

Vaccine·2026
Same journal

Effect of malaria parasitaemia on antibody responses to single-dose and two-dose HPV vaccination: results from the DoRIS dose-reduction immunogenicity trial in Tanzanian girls.

Vaccine·2026
Same journal

Public health benefits of maternal influenza vaccination among pregnant women and infants <6 months in the United States, 2011-2020.

Vaccine·2026
Same journal

Effectiveness and acceptability of an opt-out nudge to promote influenza vaccination among medical residents: A randomized controlled trial.

Vaccine·2026
See all related articles

Host genetic variations, including single nucleotide polymorphisms (SNPs) in Toll-like receptors (TLRs) and lipopolysaccharide binding protein (LBP), influence susceptibility to nosocomial infections. This review summarizes current research on these host factors.

Area of Science:

  • Immunology
  • Genetics
  • Infectious Diseases

Background:

  • Host-pathogen interactions are critical in determining outcomes of nosocomial infections.
  • Lipopolysaccharide binding protein (LBP) is a key soluble factor recognizing microbial components.
  • Toll-like receptors (TLRs) are major cellular signaling receptors for pathogens.

Purpose of the Study:

  • To summarize the current understanding of host genomic variations and infection susceptibility.
  • To highlight the role of genetic variations in LBP and TLRs.

Main Methods:

  • Review of existing studies on genetic variations and infection susceptibility.
  • Analysis of single nucleotide polymorphisms (SNPs) in genes encoding LBP and TLRs.

Main Results:

Related Experiment Videos

  • Genetic variations in host factors like LBP and TLRs are linked to susceptibility to infections.
  • Single nucleotide polymorphisms (SNPs) represent a significant area of investigation.

Conclusions:

  • Host genomic variations play a crucial role in modulating the response to pathogens.
  • Further research into genetic variations of LBP and TLRs is warranted to understand infection susceptibility.