Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autoimmunity, histocompatibility, and aging.

P J Meredith, R L Walford

    Mechanisms of Ageing and Development
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Aging is linked to immune system decline, potentially causing autoimmune diseases. Genes within the major histocompatibility complex influence immune function and disease susceptibility with age.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Association Between Partner Reactions to Chronic Pain and Pain-Related Outcomes: A Systematic Review.

    European journal of pain (London, England)·2026
    Same author

    'Handing down of beautiful knowledge': Yarning with workers about feeding practices and mealtimes in Australian First Nations families.

    Appetite·2024
    Same author

    Compression garment wear and sensory variables after burn: a single-site study.

    Burns : journal of the International Society for Burn Injuries·2020
    Same author

    Caloric restriction alters the feeding response of key metabolic enzyme genes.

    Mechanisms of ageing and development·2001
    Same author

    Chaperone-mediated regulation of hepatic protein secretion by caloric restriction.

    Biochemical and biophysical research communications·2001
    Same author

    Energy metabolism after 2 y of energy restriction: the biosphere 2 experiment.

    The American journal of clinical nutrition·2000

    Area of Science:

    • Immunology
    • Gerontology
    • Genetics

    Background:

    • The immunologic theory of aging suggests aging is tied to immune dysfunction, resembling autoimmune conditions affecting all tissues.
    • Age-related decline in immune surveillance and self/non-self discrimination increases autoimmune and immunodeficiency diseases in the elderly.

    Purpose of the Study:

    • To explore the role of the major histocompatibility complex (MHC) in age-related immune changes.
    • To investigate how MHC-linked genes influence age-specific immune parameters and disease incidence in mice.

    Main Methods:

    • Analysis of immune functional parameters in genetically homozygous mice.
    • Correlation of age-specific immune changes with genes linked to the major histocompatibility complex (MHC).

    Related Experiment Videos

    Main Results:

    • Differences in age-specific immune function peaks in mice are influenced by MHC-linked genes.
    • These genetic factors contribute to strain-dependent, age-specific incidence of diseases like autoimmune and malignant conditions.
    • Susceptibility to age-related diseases depends on the balance of immune parameters, partially controlled by MHC-linked genes.

    Conclusions:

    • MHC-linked genes play a role in modulating immune system aging and disease susceptibility.
    • The interplay of immune parameters, influenced by MHC genes, determines age-specific disease risk.