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Updated: Aug 20, 2026

Using Real-Time Cell Metabolic Flux Analyzer to Monitor Osteoblast Bioenergetics
Published on: March 1, 2022
[Obesity and bone metabolism]
Hiroyuki Koshiyama1, Kiyoshi Tanaka, Yutaka Seino
1Division of Diabetes & Endocrinology, Department of Internal Medicine, Tazuke Foundation Medical Research Institute Kitano Hospital, Department of Diabetes & Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Abstract:
It is well known that obesity is associated with increased bone mineral density. Although this phenomenon has been explained to be attributable to the mechanical burden, there have been increasing evidences indicating that some humoral factor ie. 'hormone', especially adiposity signal such as insulin or leptin, may play a role in disorders of bone metabolism associated with obesity. There have been several evidences suggesting that other hormones such as thyroid hormone, growth hormone, or glucocorticoid may also be involved.
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