Related Experiment Video
Updated: Aug 20, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
[Diabetes and osteoporosis]
Iseki Takamoto1, Takashi Kadowaki
1Department of Metabolic Disease, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Abstract:
Since Albright first proposed the concept of "diabetic osteopenia", many studies have investigated the levels of bone mineral density (BMD) and the risk of osteoporosis in type 1 and type 2 diabetes. The presence of osteoporosis in type 1 diabetes seems to be a reliable evidence. On the other hand, there is still some controversy about the risk of osteoporosis in type 2 diabetes probably due to different pathogenesis, clinical stage and environmental factors. Although details of the pathogenic mechanisms are not fully understood, low insulin secretion, insulin resistance, hyperglycemia, adipocytokines and other diabetic complications including diabetic triopathy may determine changes in diabetic bone metabolism. Recent findings suggest that several drugs for life style-related disease such as statins, beta blockers and thiazolidinediones may have a potential role to promote bone formation other than their own therapeutic effects.
Related Concept Videos
Type II Diabetes II: Pathophysiology
Type I Diabetes II: Pathophysiology
Diabetes Mellitus: Type 2 and Gestational
Complications of Diabetes Mellitus
Type I Diabetes III: Clinical Manifestations
Diabetic Neuropathy