Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[PPARgamma and bone metabolism].

Ichiro Takada1, Shigeaki Kato

  • 1The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Tokyo, Japan.

Clinical Calcium
|December 4, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

β-Catenin Does Not Co-activate Vitamin D Receptor-mediated Transcription in Osteoblastic and Non-osteoblastic Cells.

Bioscience, biotechnology, and biochemistry·2026
Same author

Synthetic Modulators of the Vitamin D Receptor: From Structural Innovation to Disease-Specific Applications.

Biomolecules·2026
Same author

Vitamin D Receptor Signaling and Ligand Modulation: Molecular Mechanisms and Therapeutic Implications.

International journal of molecular sciences·2026
Same author

Pivotal contribution of super-enhancer-driven KLF6 expression to the adipogenesis of human adipose-derived stem cells.

Inflammation and regeneration·2026
Same author

KDM4B modulates ERα signaling pathway to participate in vascular smooth muscle cell calcification.

Cell death discovery·2025
Same author

Dietary calcium intake controls epithelial expression of TRPV6 independent of 1,25(OH)<sub>2</sub>D<sub>3</sub> endocrine signaling.

Cell calcium·2025

Peroxisome proliferator-activated receptor gamma (PPARgamma) influences fat development and is linked to diabetes and obesity. This study reveals how PPARgamma works and how cytokines affect its activity in stem cells, impacting bone metabolism.

Area of Science:

  • Molecular biology
  • Cell biology
  • Endocrinology

Context:

  • Peroxisome proliferator-activated receptor gamma (PPARgamma) is a nuclear receptor involved in adipogenesis, diabetes, and obesity.
  • Emerging research suggests a role for PPARgamma in bone metabolism.
  • Bone marrow-derived mesenchymal stem cells (BMSCs) are crucial for bone formation and repair.

Purpose:

  • To elucidate the molecular mechanisms underlying PPARgamma's transcriptional activity.
  • To investigate the suppressive effects of cytokines on PPARgamma activity in BMSCs.
  • To understand the interplay between PPARgamma, cytokines, and bone metabolism.

Summary:

  • This study details the molecular mechanisms of PPARgamma transcriptional activity.
  • It demonstrates that cytokines suppress PPARgamma activity in bone marrow-derived mesenchymal stem cells.

Related Experiment Videos

  • The findings shed light on how PPARgamma regulates bone metabolism.

    • Impact:

    • Provides novel insights into the regulation of PPARgamma in stem cells.
    • Contributes to understanding the molecular basis of bone metabolism.
    • May inform therapeutic strategies for bone-related disorders associated with metabolic diseases.