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[Control of calcification by extracellular matrix]
1Department of MENICON cartilage and Bone Regeneration, Graduate School of Medicine, The University of Tokyo.
Clinical Calcium
|December 4, 2004
Summary
Physiological calcification involves hydroxyapatite crystallization, controlled by extracellular matrix organic components. This review explores molecular regulation and mineral/organic interactions in bone and tooth formation.
Area of Science:
- Biomineralization
- Extracellular Matrix Biology
- Skeletal Biology
Context:
- Calcification is a critical physiological process for bone and tooth development.
- It involves the controlled deposition of hydroxyapatite crystals.
- The extracellular matrix (ECM) plays a pivotal role in regulating this process.
Purpose:
- To discuss the molecular mechanisms underlying physiological calcification.
- To highlight the role of organic ECM components in controlling calcification.
- To focus on the intricate mineral/organic interactions during calcification.
Summary:
- Physiological calcification initiates with hydroxyapatite crystallization within the ECM of bones and teeth.
- As an extracellular event, calcification is significantly influenced by the organic constituents of the ECM.
- This work reviews the molecular regulation of calcification, emphasizing the interplay between mineral and organic phases.
Impact:
- Provides insights into the molecular basis of skeletal and dental development.
- Enhances understanding of biomineralization processes.
- Offers a foundation for investigating calcification disorders.