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IL-7 and Flt-3L plasma levels are increased during highly active antiretroviral therapy-associated IL-2 therapy

Stéphanie Beq1, Arnaud Fontanet, Jacques Theze

  • 1Unité d'ImmunoGénétique Cellulaire, Institut Pasteur, Paris, France.

AIDS (London, England)
|December 4, 2004
PubMed

IL-2 is used in conjunction with highly active antiretroviral therapy to increase the CD4 cell count in HIV-positive patients. The mechanisms involved remain ill-defined. Here we show that during the first cycle of IL-2 therapy, IL-7 and Flt-3L plasma levels are increased, whereas levels of stem cell factor are unchanged. This supports the hypothesis that aside from stimulating CD4 T cells IL-2 may also indirectly affect lymphocyte production through the stimulation of lymphopoietic cytokines.

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