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Intralesional interferon alfa-2b treatment of keratoacanthomas
Chang-Keun Oh1, Hyo-Sung Son, Jae-Bong Lee
1Department of Dermatology, Pusan National University College of Medicine, Busan, Korea. ckoh@pusan.ac.kr
Background:
Complete excision is not always easy when a keratoacanthoma is large or located in certain anatomic areas. An effective nonsurgical treatment would be desirable in such cases.
Objective:
This was a pilot study of the effects of intralesional interferon alfa-2b in the treatment of rapidly growing keratoacanthomas.
Methods:
A total of 4 large, rapidly growing keratoacanthomas, which were located on the lower lip, neck, and cheeks of the 4 different patients, were treated with intralesional interferon alfa-2b injection weekly. Serial photographs were taken to observe the course of responses.
Results:
All lesions resolved completely in 5 to 7 weeks with acceptable cosmetic results.
Conclusion:
Intralesional interferon alfa-2b can be a treatment modality of these difficult lesions.
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