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Regulation of immunity by lysosphingolipids and their G protein-coupled receptors

Edward J Goetzl1, Hugh Rosen

  • 1Department of Medicine, UCSF, San Francisco, California, USA. egoetzl@itsa.ucsf.edu

The Journal of Clinical Investigation
|December 4, 2004
PubMed

T and B lymphocytes, as well as endothelial cells, express distinctive profiles of G protein-coupled receptors for sphingosine 1-phosphate, which is a major regulator of T cell development, B and T cell recirculation, tissue homing patterns, and chemotactic responses to chemokines. The capacity of drugs that act on type 1 sphingosine 1-phosphate receptors to suppress organ graft rejection in humans and autoimmunity in animal models without apparent impairment of host defenses against infections suggests that this system is a promising target for new forms of immunotherapy.

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