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Related Experiment Videos

Annular lichen planus.

Kanako Sakakibara1, Tokio Nakada, Hirohiko Sueki

  • 1Department of Dermatology, Showa University School of Medicine, 1-5-8, Hatanodai, Shinagawa-ku, 142-8666, Tokyo, Japan.

Journal of Cutaneous Medicine and Surgery
|December 4, 2004
PubMed
Summary
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Annular lichen planus presents as distinct lesions. Inflammation may cause elastolysis, leading to characteristic skin changes and potential recurrence despite treatment.

Area of Science:

  • Dermatology
  • Pathology

Background:

  • Annular lichen planus is a variant of lichen planus characterized by annular plaques with active rims and depressed centers.
  • This study details two cases of annular lichen planus in adult women.

Observation:

  • Lesions predominantly appeared in the femoral regions in both patients.
  • Histopathology revealed epidermal liquefaction degeneration and a band-like lymphocytic infiltrate at the lesion margins.
  • The center of the lesions showed less dermal infiltrate and fragmented elastic fibers compared to the margins.

Findings:

  • Histopathological analysis indicated elastolysis, evidenced by fragmented elastic fibers in the central depressed areas.
  • Inflammation was more pronounced at the active rim of the lesions.

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Implications:

  • The observed elastolysis suggests a potential mechanism for the characteristic depressed center in annular lichen planus.
  • Recurrence of lesions was noted in one case despite topical corticosteroid treatment, indicating the need for further understanding of disease behavior.