Related Experiment Video

Updated: Aug 20, 2026

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis
08:48

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

[Efficiency of voriconazole in fungal keratitis caused by candida albicans]

J M Granados1, N Puerto, M J Carrilero

  • 1Servicio de Oftalmología, Complejo Hospitalario Universitario de Albacete (SESCAM), Spain. jgranadosm@ono.com

Archivos De La Sociedad Espanola De Oftalmologia
|December 4, 2004
PubMed
Abstract

Insights

A severe Candida albicans fungal keratitis case highlights voriconazole

Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Candida albicans fungal keratitis can rapidly progress to corneal perforation despite standard treatments.
  • Effective management of severe fungal keratitis requires prompt and aggressive therapeutic strategies.

Observation:

  • A 70-year-old woman with diabetes and prior corneal ulceration developed severe Candida albicans keratitis.
  • Initial treatment with topical amphotericin B and oral itraconazole failed, leading to corneal perforation.

Findings:

  • Emergency amniotic membrane transplant combined with systemic voriconazole successfully resolved the fungal infection.
  • Despite successful infection control, penetrating keratoplasty was necessary to restore corneal transparency.

Implications:

  • Systemic voriconazole demonstrates significant efficacy in managing severe ocular fungal infections, including those caused by Candida albicans.
  • This case underscores the aggressive nature of Candida keratitis and the potential need for advanced surgical interventions alongside novel antifungal therapies.

More Related Videos

Candida albicans Biofilm Chip (CaBChip) for High-throughput Antifungal Drug Screening08:05

Candida albicans Biofilm Chip (CaBChip) for High-throughput Antifungal Drug Screening

Published on: July 18, 2012

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

Related Concept Videos

Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...