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Apoptotic cell death in canine hair follicle

L Pascucci1, V Pedini, F Parillo

  • 1Department of Biopathological Veterinary Sciences, School of Veterinary Medicine, University of Perugia, Italy. anatvet@unipg.it

Histology and Histopathology
|December 4, 2004
PubMed

Insights

Apoptotic cell death, marked by DNA fragmentation, occurs during both hair growth and regression in dogs. This study defines the timing of apoptosis in canine hair biology.

Area of Science:

  • Veterinary Dermatology
  • Cell Biology
  • Animal Physiology

Background:

  • Apoptotic cell death is crucial for tissue homeostasis and cellular turnover.
  • Morphological and biochemical hallmarks include condensation and DNA fragmentation.
  • Previous studies linked apoptosis to hair cycle phases in various species.

Purpose of the Study:

  • To investigate the role and timing of apoptosis in canine hair biology.
  • To establish the spatio-temporal relationship between apoptosis and the canine hair cycle.

Main Methods:

  • Terminal deoxynucleotidyl transferase-mediated d-UTP nick-end labeling (TUNEL) assay.
  • Histological and ultrastructural examinations of canine hair follicles.

Main Results:

  • Apoptotic cells were identified in canine hair follicle epithelium during both growing (anagen) and regressing (catagen) phases.
  • The observed apoptotic features were consistent with established literature.

Conclusions:

  • Apoptosis is an integral component of the canine hair cycle.
  • Understanding apoptosis timing aids in comprehending canine hair biology and potential disorders.

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