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Updated: Aug 19, 2026

Strategies for Tracking Anastasis, A Cell Survival Phenomenon that Reverses Apoptosis
Published on: February 16, 2015
Nuclear or cytoplasmic expression of survivin: what is the significance?
Fengzhi Li1, Jie Yang, Nithya Ramnath
1Department of Pharmacology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. fengzhi.li@roswellpark.org
Abstract:
Growing evidence suggests that survivin expression in cancer cell nuclei may represent an important prognostic marker to predict disease outcome for cancer patients. Current reports in this research area, however, are inconsistent and propose opposing conclusions regarding the significance and prognostic value of survivin nuclear expression. The aim of our study is to review and discuss the data reported in the original publications. We have also provided new experimental data to support our view regarding the possible reasons for the observed inconsistencies in the literature. This would alert researchers to pay attention to potential pitfalls in the determination of nuclear or cytoplasmic expression of survivin for the future.
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