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Related Experiment Videos

Disintegrins.

Mary Ann McLane1, Elda E Sanchez, Alice Wong

  • 1Department of Medical Technology, University of Delaware, Newark, DE 19716, USA. mclane@udel.edu

Current Drug Targets. Cardiovascular & Haematological Disorders
|December 8, 2004
PubMed
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Disintegrins, small proteins from viper venom, are crucial in cellular research and therapeutic design for thrombosis and cancer. New discoveries since 1998 reveal their expanded roles in molecular mechanisms and targeted therapies.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • Disintegrins are small, non-enzymatic proteins found in viper venom, known for their significant impact on cellular research for two decades.
  • They serve as molecular scaffolds for developing therapeutics targeting thrombosis and cancer.
  • Their structural homologies extend to disintegrin-like molecules in diverse species, including humans.

Purpose of the Study:

  • To review disintegrin family members discovered since 1998.
  • To highlight the expanded understanding of their therapeutic potential.
  • To discuss their utility in technical assays and molecular investigations.

Main Methods:

  • Review of scientific literature focusing on disintegrins discovered post-1998.

Related Experiment Videos

  • Analysis of studies investigating disintegrin roles in cellular processes and disease.
  • Examination of research on recombinant disintegrin mutants and fusion proteins.
  • Investigation of disintegrin applications in drug delivery systems (microbubbles, liposomes).

    • Main Results:

    • Identification of novel disintegrin family members and their functions.
    • Elucidation of disintegrins' roles in intracellular signaling pathways (apoptosis, motility, proliferation, viral pathogenesis).
    • Demonstration of disintegrin-targeted delivery to neovascular endothelium and metastatic tumors in mouse models.
    • Advancement in understanding cell-extracellular matrix interactions through disintegrin research.

    Conclusions:

    • Disintegrins continue to be vital tools in cellular research and drug development.
    • Recent discoveries have broadened the scope of disintegrin applications in medicine and biotechnology.
    • Further research into disintegrins promises enhanced therapeutic strategies and diagnostic tools.