Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Herpesvirus/retrovirus chimeric vectors.

Alberto L Epstein1, Roberto Manservigi

  • 1Centre de Génétique Moléculaire et Cellulare, UMR5534 CNRS, Université Claude Bernard Lyon I, 69622 Villeurbanne, France. epstein@biomserv.univ-lyon1.fr

Current Gene Therapy
|December 8, 2004
PubMed
Summary

This review explores herpesvirus/retrovirus chimeric vectors, which combine herpes simplex virus type 1 (HSV-1) and retroviral features for enhanced gene delivery and stable integration. These hybrid vectors offer improved efficacy for various applications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-replicative herpes simplex virus genomic and amplicon vectors for gene therapy - an update.

Gene therapy·2024
Same author

Safety of non-replicative and oncolytic replication-selective HSV vectors.

Trends in molecular medicine·2024
Same author

Herpes simplex virus gene therapy for dystrophic epidermolysis bullosa (DEB).

Cell·2023
Same author

AAV-mediated neuronal expression of an scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models.

Molecular therapy : the journal of the American Society of Gene Therapy·2022
Same author

HSV-1's contribution as a vector for gene therapy.

Nature biotechnology·2022
Same author

Development and Assessment of Herpes Simplex Virus Type 1 (HSV-1) Amplicon Vectors with Sensory Neuron-Selective Promoters.

International journal of molecular sciences·2022

Area of Science:

  • Virology
  • Gene Therapy
  • Molecular Biology

Background:

  • Herpes simplex virus type 1 (HSV-1) based vectors have evolved from defective viruses to amplicon vectors.
  • Hybrid or chimeric vectors integrate elements from different viruses to improve gene delivery efficacy.
  • Herpesvirus/retrovirus chimeras leverage HSV-1's transduction efficiency and episomal maintenance for gene delivery.

Purpose of the Study:

  • To review herpesvirus/retrovirus chimeric vectors.
  • To highlight their application in generating retrovirus particles, vaccine development, and studying protein targeting.
  • To discuss advancements in gene delivery systems.

Main Methods:

  • Review of existing literature on herpesvirus/retrovirus chimeric vectors.
  • Analysis of vector design strategies combining HSV-1 and retroviral elements.

Related Experiment Videos

  • Discussion of applications in gene therapy and vaccine development.

    • Main Results:

    • Herpesvirus/retrovirus chimeric vectors efficiently transduce large genetic sequences, remaining episomal.
    • These vectors enable the production of recombinant retrovirus vectors for stable genomic integration.
    • The review focuses on three specific applications of these chimeric vectors.

    Conclusions:

    • Herpesvirus/retrovirus chimeric vectors represent an advanced gene delivery system.
    • They offer a versatile platform for gene therapy, vaccine development, and biological studies.
    • Continued development of these hybrid vectors promises enhanced efficacy and broader applications.