Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endogenous and exogenous nitrates.

E E Anggård1

  • 1William Harvey Research Institute, St. Bartholomew's Hospital Medical College, London, UK.

Acta Anaesthesiologica Scandinavica. Supplementum
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased levels of plasma 8-EPI-PGF2α in patients with end stage renal failure.

Redox report : communications in free radical research·2016
Same author

Microassay of superoxide anion scavenging activity in vitro.

Environmental toxicology and pharmacology·2011
Same author

Physiological microassay of plasma total antioxidant status in a model of endothelial dysfunction in the rat following experimental oxidant stress in vivo.

Environmental toxicology and pharmacology·2011
Same author

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy.

Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2009
Same author

Investigation of basal endothelial function in the obese Zucker rat in vitro.

General pharmacology·2002
Same author

Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism.

Diabetologia·2001
Same journal

Abstracts from the Scandinavian Society of Anaesthesiologists, 30th Congress, 10-13 June 2009, Odense, Denmark.

Acta anaesthesiologica Scandinavica. Supplementum·2009
Same journal

Abstracts from the 29th Congress of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine, 5-8 September 2007, Goteborg, Sweden.

Acta anaesthesiologica Scandinavica. Supplementum·2007
Same journal

Abstracts from the 28th Congress of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine, Reykjavik, Iceland.

Acta anaesthesiologica Scandinavica. Supplementum·2005
Same journal

Abstracts from the 27th Congress of The Scandinavian Society of Anaesthesiology and Intensive Care Medicine. August 16-20, 2003, Helsinki, Finland.

Acta anaesthesiologica Scandinavica. Supplementum·2003
Same journal

Abstracts from the 26th Congress of the Scandinavian Society of Anaesthesiology and Intensive Care Medicine. June 13-17, 2001. Tromso, Norway.

Acta anaesthesiologica Scandinavica. Supplementum·2001
Same journal

The Scandinavian Society of Anaesthesiologists 25th Congress. Aarhus, Denmark, June 9-11, 1999. Abstracts.

Acta anaesthesiologica Scandinavica. Supplementum·1999
See all related articles

Endothelium-derived relaxing factor (EDRF), primarily nitric oxide (NO), aids blood vessel relaxation and prevents platelet aggregation. Its deficiency in diseases like hypertension impairs this function, but nitrates can help.

Area of Science:

  • Biochemistry
  • Physiology
  • Vascular Biology

Background:

  • Endothelium-derived relaxing factor (EDRF) is identified as nitric oxide (NO) or related nitrosothiols.
  • NO is synthesized from L-arginine and has a short local half-life, being rapidly inactivated in blood by hemoglobin.

Purpose of the Study:

  • To elucidate the mechanism of EDRF-NO action.
  • To understand the implications of EDRF-NO deficiency in cardiovascular diseases.
  • To explore therapeutic strategies for impaired endogenous NO production.

Main Methods:

  • Review of biochemical pathways for NO synthesis and action.
  • Analysis of physiological consequences of NO in vascular and platelet function.
  • Examination of EDRF-NO levels in disease states like hypertension, atherosclerosis, and diabetes.

Related Experiment Videos

Main Results:

  • EDRF-NO activates soluble guanylate cyclase, increasing cyclic GMP (cGMP) levels.
  • Elevated cGMP induces vasodilation and inhibits platelet aggregation.
  • Endothelium-dependent vasodilation is reduced in hypertension, atherosclerosis, and diabetes due to endothelial dysfunction or loss.

Conclusions:

  • Impaired endogenous nitric oxide (NO) formation contributes to vascular dysfunction in common diseases.
  • Exogenous nitrate therapy can compensate for deficient EDRF-NO production.
  • Understanding NO's role is crucial for managing cardiovascular health.